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. 2020 Jul 8;10:11236. doi: 10.1038/s41598-020-67908-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of let-7c on EMT and CSC markers. (A) H1975 cells or (B) HCC827-T790M cells were transfected with non-specific (control) or pre-let-7c (upper panels) or anti-let-7c (lower panels) and the mRNA expression of EMT markers (E-cadherin and ZEB1) tested by quantitative RT-PCR. (C) H1975 cells or (D) HCC827-T790M cells were also transfected with non-specific (control) or pre-let-7c (upper panels) or anti-let-7c (lower panels) and the mRNA expression of CSC marker SOX2 tested by quantitative RT-PCR. β-actin served as internal control. *p < 0.05 and **p < 0.01, relative to control.