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. 2020 Jul 8;10:11236. doi: 10.1038/s41598-020-67908-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of let-7c on response to Osimertinib. (A) H1975 cells or (B) HCC827-T790M cells were transfected with non-specific (control) or pre-let-7c or anti-let-7c and then treated with increasing doses, as indicated, of Osimertinib for 72 h, followed by determination of proliferation of cells by XTT assay. Cells at 0 nM Osimertinib were considered to be 100% and relative % of cells are plotted. **p < 0.01, relative to control.