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. 2020 Jul 8;10:11236. doi: 10.1038/s41598-020-67908-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Let-7c targets affect response to Osimertinib and in vivo effects of let-7c. (A) H1975 cells or (B) HCC827-T790M cells were silenced for WNT1 or TCF-4, using specific siRNAs, and then treated with various indicated doses of Osimertinib for 72 h. Thereafter, proliferation of cells was tested by XTT assay. (C) H1975 cells or (D) HCC827-T790M cells (control or transfected with either pre- or anti-let-7c) were implanted in SCID mice (n = 10 pergroup) for in vivo xenograft study and the tumor volume was calculated, as described in the Methods. Levels of let-7c targets, wnt1 (E) and TCF-4 (F) were evaluated in the tumors from control vs pre-let-7c groups of H1975 xenografts. **p < 0.01, relative to control.