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. 2020 Jul 8;10:11208. doi: 10.1038/s41598-020-67693-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The treatment of 100 μM Propofol for 48 h (Panel B) or NET1 silencing (Panel D) significantly inhibited SMMC-7721 cell invasion compared to control group (Panel A) and NC group (Panel C).While (E) the inhibitory effect of propofol was offset by NET1 overexpression (Panel E). Statistical analysis on SMMC-7721 cell invasion with indicted treatment (Panel F). **P < 0.01 compared with control group, n.s. represented no significance compared with control group, # and ## denote P < 0.05, 0.01 compared with si-NET1 group.