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. 2020 Jul 8;10:11213. doi: 10.1038/s41598-020-68178-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Proposed regulatory mechanisms of blood circulation for hypoxic adaptation in Tibetan chickens. These genes, marked with red color, are involved in HIF-1, VEGF, MAPK, mTOR, PI3K-Akt, Notch, Insulin, focal adhesion signaling pathway, Renin-angiotensin system, vascular smooth muscle contraction and oxygen binding. These pathways and genes indicate Tibetan chickens adapt to hypoxia by regulating angiogenesis and promoting blood circulation (green circles)⁵⁶.