. 2020 Jul 8;10:11213. doi: 10.1038/s41598-020-68178-w

Table 1.

Potential key differentially expressed genes (DEGs) and their functions related to hypoxic adaptation in the Tibetan chicken.

	Gene symbol	Log₂FC of TC/CH in transcriptome	P value in transcriptome	FC of TC/CH in proteome	P value in proteome	Functional analysis
Angiogenesis, blood circulation	HSPB1	1.35878	3.20E−11	1.337911	0.01458	Blood vessel morphogenesis, vasculature development, angiogenesis, VEGF signaling pathway, MAPK signaling pathway, response to wounding
	PRRX1	2.9814	3.22E−05			Blood vessel morphogenesis, vasculature development, angiogenesis, circulatory system development, embryonic morphogenesis
	NRXN1	1.15815	0.007762			Blood vessel morphogenesis, vasculature development, angiogenesis, circulatory system development
	NGFR	1.0405	0.003605			Blood vessel morphogenesis, vasculature development, angiogenesis, response to oxygen-containing compound, inflammatory response
	ACE2	− 2.81573	0.004862			Regulation of blood circulation, ion transport
	IL8	1.27992	0.000488			Inflammatory response, blood vessel morphogenesis, vasculature development, NOD-like receptor signaling pathway
	LVRN	3.37668	0.004667			Regulation of blood circulation
	CASQ2	2.66033	0.000188			Regulation of blood circulation
	HK2	0.518702	0.013336	1.238302	0.04188	HIF-1 signaling pathway, insulin signaling pathway, ATP binding, reactive oxygen species metabolic process
	PPP1CB	0.009335	0.957726	1.271042	0.01563	Vascular smooth muscle contraction, focal adhesion, insulin signaling pathway, regulation of glucose metabolic process
	Notch2	0.581222	0.00163	1.356528	0.02125	Notch signaling pathway
	NUMB	0.275351	0.128049	1.246141	0.02506	Notch signaling pathway, respiratory system development
	NLN	-0.2943	0.202168	1.359688	0.03799	Renin-angiotensin system, regulation of glucose metabolic process
	AGT	0.760166	0.237922	0.833058	0.00249	Renin-angiotensin system, blood circulation, regulation of blood pressure, vascular smooth muscle contraction
	CTSA	0.174747	0.347873	0.806236	0.00921	Renin-angiotensin system
	EMP2	− 0.31835	0.085554	0.828718	0.01851	Blood vessel development, angiogenesis, blood circulation, regulation of blood pressure
	ALB	− 0.70844	0.181368	0.654163	0.04703	Oxygen binding
	MLST8	0.17267	0.38606	1.402026	0.01272	mTOR signaling pathway, PI3K-Akt signaling pathway
	VAV2	0.005034	0.97868	1.241425	0.01637	Focal adhesion, cAMP signaling pathway
	PPP1R12A	− 0.385	0.077303	0.68122	0.02216	Vascular smooth muscle contraction, Focal adhesion, cAMP signaling pathway
	STK4	0.06014	0.736915	1.289501	0.02507	Angiogenesis, blood vessel development, MAPK signaling pathway, Ras signaling pathway, pathways in cancer
	NCALD	0.12793	0.763732	1.236695	0.01668	Blood circulation, regulation of blood pressure
	PLCB1	− 0.06643	0.793429	0.691824	0.02702	Vascular smooth muscle contraction, calcium signaling pathway, Wnt signaling pathway, pathways in cancer
	CKI	0.010574	0.9535	1.431694	0.04621	Angiogenesis, blood vessel development, carbohydrate metabolic process
	APOH	0.765486	0.313575	0.489209	0.0491	Angiogenesis, blood vessel development
	GNG2	0.167516	0.608336	1.342209	0.00533	Angiogenesis, blood vessel development, PI3K-Akt signaling pathway, Ras signaling pathway, pathways in cancer
Ion transport	TF	1.25436	9.22E−11	1.317705	0.04102	Ion transport, HIF-1 signaling pathway
Ion transport	CACNA1H	1.18814	0.002184			Ion transport
Energy metabolism	SCD	1.07335	0.003772			Fatty acid metabolism
	NR4A3	1.69574	5.53E−09			Fatty acid oxidation, cellular respiration, embryonic morphogenesis
	FABP3	− 0.12569	0.506738	0.826003	0.01895	PPAR signaling pathway, fatty acid metabolic process
	AKT2	0.071846	0.783787	1.259509	0.02436	ATP binding, regulation of fatty acid oxidation, ion transport, regulation of glucose metabolic process
	IDH3B	0.089861	0.744915	1.242099	0.02527	NAD binding, cellular respiration
	SIRT5	0.087213	0.737814	1.380089	0.00174	NAD binding, reactive oxygen species metabolic process