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. 2020 Jul 8;11:3412. doi: 10.1038/s41467-020-17179-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a IL-10 expression in human B cells stimulated through TLR9± pan inhibition of PI3K (PI3Ki, ZSTK474) (n = 4, pval = 0.008). b IL-10 expression in human B cells stimulated through TLR9± inhibitors for specific family members of PI3K: these being δ (Nemiralisib), γ (IP-549), or α (HS-173), over a range of concentrations (n = 4). c IL-10 and TNF expression in mouse B cells after stimulation through TLR9. Mice used were wild type (WT), hyperactive PI3Kδ (E1020K), or catalytically inactive PI3Kδ (D910A) (n = 3, pval = 0.002 and <0.0001). Each data point represents individual donors or mice. Data presented are mean ± SD. Statistical testing in figures in a was done by a paired t test, or in c by a one-way ANOVA with Dunnet’s multiple comparisons test. **P < 0.01, ****P < 0.0001 and all significant values are shown.