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. 2020 Jul 8;10:11199. doi: 10.1038/s41598-020-67792-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Clinical features of CRD patients; A F6, RE fundus of patient II.1. B F7, RE of patient II.1. C, D, E, F and G Clinical features of patients from F8. C: Fundus imaging of RE of index patient III.2. D FAF showing central macular hypoFAF surrounded by ring of hyper FAF, small areas of hypoFAF in the mid-periphery. E SS-OCT showing vitreo-retinal traction with macular hole. F fundus photo of the right eye of patient III.3. G SS-OCT showing diffuse chorio-retinal atrophy. H, I, J, K, L, M, N, O and P Clinical features of patients from F9. H Fundus imaging of LE of patient IV.4. I FAF showing central macular hypoFAF surrounded by ring of hyper FAF. J SS-OCT showing macular atrophy. K fundus photo of the left eye of the sister IV.6. L FAF showing central macular hypoFAF surrounded by ring of hyper FAF. M SS-OCT showing macular atrophy. N fundus photo of the left eye of IV.2. O FAF large macular atrophy surrounded smaller areas of atrophy. P SS-OCT showing macular atrophy with parafoveolar gliosis. Q, R and S Clinical features of patients from F9 showing cloverleaf maculopathy with peripheral RPE atrophy.