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. 2020 Jul 8;10:11239. doi: 10.1038/s41598-020-67724-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Dose-dependent active electrode count and mean spike rate versus time for MEA neuron cultures. (a) Plot of total number of active electrodes versus time, normalized to the total number of active electrodes originally spiking at a given MIRB dose at 0 h (pretreatment). For each dose, MIRB nanoparticles were incubated for 2 h before removal. At the dose of 40 µg/ml, no active electrodes were detected at 4 h or later and those MEA data were not further analyzed. We found that prior to incubation with 0 (control), 5, 10, 20, or 40 µg/ml MIRB nanoparticles, there were 30, 41, 15, 19, and 17 active electrodes (> 0.03 Hz) per MEA on average (out of 60 possible electrodes), respectively. Error bars are Poisson counting errors. (b) Mean spike rates of active electrodes versus time. Error bars denote standard error of the mean.