Table 3.
Descriptive and qualitative analysis of primary endpoint events.
| Patient | Diagnosis | Age (years) | Cycle # | Height (cm) /weight (kg) /Body Surface Area (m2) | eGFR (CKD-EPI, ml/min/1.73m2) | Urinary Creatinine Clearance (uCrCl, ml/min/1.73m2) | Outcome | Chemotherapy administered without delay? |
|---|---|---|---|---|---|---|---|---|
| #1 | Testicular cancer | 26 | 4 |
180 cm 69 kg 1.87m2 |
120 | 45 | uCrCl was repeated the next day and was 118 ml/min/1.73m2 | Yes |
| #2 | Testicular cancer | 47 | 3 |
178 cm 73 kg 1.90m2 |
102 | 37 | uCrCl was repeated the next day and was 104 ml/min/1.73m2 | Yes |
| #3 | Biliary tract cancer | 68 | 4 |
170 cm 73 kg 1.84m2 |
97 | 19 | Suspected incompliance with 24-h urine collection, uCrCl was repeated the next day and was 79 ml/min/1.73m2 | Yes |
| #4 | Testicular cancer | 37 | 1 |
171 cm 65 kg 1.76m2 |
63 | 41 | Chemotherapy was administered despite uCrCl result of 41 because of vital indication (extensive metastatic disease) | Yes |
| #5 | Biliary tract cancer | 69 | 2 |
159 cm 47 kg 1.45m2 |
105 | 50 (49.8) | Result was rounded to 50 by treating physician | Yes |
| #6 | Biliary tract cancer | 36 | 1 |
180 cm 84 kg 2.04m2 |
107 | 46 | Suspected incompliance with 24-h urine collection, uCrCl was repeated 8 days later and was 69 ml/min/1.73m2 | Yes |
| #6 | Biliary tract cancer | 36 | 3 |
180 cm 84 kg 2.04m2 |
113 | 13 | Suspected incompliance with 24-h urine collection, uCrCl was repeated 14 days later and was 93 ml/min/1.73m2 | Yes |
| #7 | CUP syndrome | 48 | 4 |
193 cm 78 kg 2.08m2 |
114 | 50 (49.1) | Suspected incompliance with 24-h urine collection, uCrCl was repeated the next day and was 37 ml/min/1.73m2 (Patient incompliant with 24-h urine collection also in inpatient setting) | Yes |
eGFR estimated glomerular filtration rate, CKD-EPI chronic kidney disease epidemiology collaboration equation, uCrCl urinary creatinine clearance, CUP cancer of unknown primary.