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. 2020 Jul 2;11:389. doi: 10.3389/fendo.2020.00389

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Copyright © 2020 Klein Hazebroek and Keipert.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic overview of publications investigating the effect of cold exposure on circulating FGF21 and Fgf21 expression levels in various tissues of the WT control mice. Blue box, FGF21 was up-regulated; yellow box, FGF21 was down-regulated; white box, FGF21 not differently regulated vs. control; gray box, not analyzed. The data represent circulating levels and mRNA expression, unless otherwise specified. WAT, white adipose tissue (subcutaneous unless otherwise stated); BAT, brown adipose tissue. Keipert et al. a (13), b (14). Parts of this cartoon were created using Servier Medical Art (http://smart.servier.com).