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. 2020 Jul 2;11:1347. doi: 10.3389/fimmu.2020.01347

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Copyright © 2020 Rozenbaum, Meir, Aharony, Itzhaki, Schachter, Bank, Jacoby and Besser.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo activity of γδCAR-T cells. (A) Human leukemia (Nalm6) gated on CD45+ CD10+ in the bone marrow of NSG-mice either untreated or treated with un-transduced γδT cells, γδCAR-T, or sCAR-T cells after 14 days. (B) Human leukemia (Nalm6) gated on CD45+ CD10+ in the bone marrow of NSG-mice either untreated or treated with zoledronate (Zol) alone, Zol with γδCART cells, or repeated dose of Zol and γδCAR-T. (C) Human effector cell persistence of.i.v. injected sCAR-T, γδCAR-T, and un-transduced γδ-T cells in mice bone marrow (upper panel) and spleen (lower panel), 3 days post injection. **P ≤ 0.01, ***P ≤ 0.001, Two tailed paired T-test. Bars are at the median value, and error bars represent interquartile range.