Figure 1.

Schematic diagram of protein dynamics of cytosolic DNA-sensing signaling antiviral innate immunity signaling pathways. Cytosolic DNA sensors, such as cGAS and TLR9, recognize dsDNA and trigger IFN-I production through the transmission of a series of signals. Multiple steps in the DNA-sensing signaling pathways can be modulated by host and viral proteins. Green lines indicate that host proteins target adaptors. Red lines indicate that viral proteins interfere with adaptors. CBP, CREB-binding protein; P, phosphate; U, ubiquitin.