Table 1.

Demographic data for the total group of patients, the two subgroups of patients with and without postoperative hypothalamic lesions (HL), and the healthy control group.

	All patientsa	Patients without postop HL	Patients with postop HL	All controls	All patients vs. controls (p-value)	Patients without HL vs. with HL (p-value)	Patients with HL vs. controls (p-value)
N	29	7	22	34
% Female gender	58.6	57.1	59	55.9	0.803	1	0.8
Age at study	20 (11) range: 7–38	20 (11) range: 7–32	19.5 (10) range: 12–38	23.5 (13) range:8–40	0.26	0.74	0.36
Age at diagnosis	10.9 (6.6)	9.5 (7)	11 (7)	–	–	0.098	–
BMI SDS	4.3 (6.6)	1.6 (1.1)	5.5 (5)	0.42 (1.5)	<0.001***	0.008**	<0.001***
% Radiation therapy	41,4	42.9	40.9	–	–	1	–
n Baseline OSC	24	6	18	31
Baseline OSC	3.3 (3.6)	2.7	3.61 (3.3)	4.42 (7.6)	0.329	–	0.474
n BDI-II	21	5	16	31
BDI-II raw scores	6 (11)	6	6 (10)	4 (5)	0.091	–	0.051
% With moderate/severe depressive symptoms in BDI	0	0	0	2.9/0	–	–	–
n STAI	22	5	17	30
STAI state	34.5 (16)	34	36 (17)	31.5 (6)	0.04	–	0.092
STAI trait	40 (16)	36	40 (16)	35.5 (8)	0.121	–	0.061
% exceeding +1.5 SD in STAI trait	13.8	0	18.2	2.9	–	–	–

Medians and interquartile ranges (IQR, in brackets) are depicted, unless otherwise specified. For n <7 (see patients without hypothalamic lesions), IQR and statistical test results were not computed. With the exception of gender (χ2- test), all analyses were performed with the Mann-Whitney U-test.

^*p < 0.05;

^**p < 0.01;

^***p < 0.001.

BMI SDS, body mass index standard deviation scores; OSC, oxytocin saliva concentration. BDI, Beck Depression Inventory; STAI, State-Trait-Anxiety Inventory.

^aincluding patients with and without postoperative HL.