Table 4.

Experimental task results and demographic and clinical variables for patients with postoperative hypothalamic lesions (HL) and controls participating in the MASC.

Movie for the Assessment of Social Cognition (MASC)
	All patientsa	Patients with postop HL	All controls	All patients vs. all controls (p-value)	Patients with HL vs. all controls (p-value)
Task Performance
n	22	17	31
n Incorrect ToM	12 (9)	13 (8)	9 (6)	0.138	0.004**
n Undermentalizing (Reduced ToM)	6.5 (3.8)	7 (3)	3 (4)	0.032*	0.001**
n Overmentalizing (Excess ToM)	5 (5)	6 (5)	5 (4)	0.736	0.245
n Correct control questions	5 (1)	5 (2)	5 (2)	0.386	0.162
Demographic and Clinical Variables
n	22	17	31
% Female gender	63.6	64.7	54.8	0.581	0.555
Age at study (years)	20 (12) range: 12–38	18 (13) range: 12–38	24 (12) range: 12–40	0.333	0.261
Age at diagnosis (years)	10.9 (6.3)	10.9 (7.4)	–	–	–
BMI SDS	4.7 (5.1)	5.51 (3.85)	0.42 (1.79)	<0.001***	<0.001***
% Radiation therapy	36.4	35.3	–	–	–
n Baseline OSC	19	14	29
Baseline OSC	3.7 (3.8)	3.84 (3.44)	4.42 (8.17)	0.441	0.515
n BDI-II	18	13	30
BDI-II (raw scores)	6 (11)	6 (11)	4 (5)	0.096	0.062
n STAI State	18	13	29
STAI State (raw scores)	34 (14)	34 (16)	31 (6)	0.07	0.085
n STAI Trait	18	13	28
STAI Trait (raw scores)	39 (13)	40 (15)	35 (7)	0.165	0.126

For the experimental task, number of errors are depicted and the primary measure is highlighted in bold. Medians and interquartile ranges (in brackets) are shown, unless otherwise specified. With the exception of gender where we used the χ2- test, all analyses were performed with the Mann-Whitney U-test.

^*p < 0.05;

^**p < 0.01;

^***p < 0.001.

HL, hypothalamic lesion. ToM, Theory of Mind; BMI SDS, body mass index standard deviation scores; OSC, oxytocin saliva concentration. BDI, Beck Depression Inventory; STAI, State-Trait-Anxiety Inventory.

^aincluding patients with and without postoperative HL.