FIG 7.
Systematic search for conserved regions in paramyxo- and pneumoviruses. (A) Number of conserved regions in the different ORFs when comparing NiV with MeV, HPIV3, and HPIV2, respectively. Conserved regions were most abundant in the L protein. (B) Selection of conserved regions with an average of more than 50% homology among all paramyxo- and pneumoviruses; F117–134 is the full fusion peptide (NiV numbering). Graph shows how conserved the regions of interest are in a selection of viruses, using NiV as a reference sequence. CDV, canine distemper virus; MeV, measles virus; NiV, Nipah virus; HeV, Hendra virus; HPIV, human parainfluenza virus; MuV, mumps virus; HMPV, human metapneumovirus; HRSV, human respiratory virus.