Table 1.
Demographic Data for the Entire Study Population
| Female | Male | ||||||
|---|---|---|---|---|---|---|---|
| CAH | CAH-DEX | C | CAH | CAH-DEX | C | P Value (CAH) CAH vs C | |
| Number of patients | 17 | 6 | 27 | 15 | 5 | 25 | |
| Age, mean (SD) | 11.2 (3.2) | 11.8 (3.8) | 10.6 (2.5) | 11.7 (2.6) | 11.5 (0.9) | 11.0 (2.1) | 0.215 |
| HC (mg/m 2 ), mean (SD) | 12.5 (3.4) | 12.4 (3.6) | N/A | 11.3 (1.5) | 14.6 (2.5) | N/A | |
| Fludrocortisone (μg), mean (SD) | 110.73 (47.7) | 75.04 (25.0) | 96.45 (39.0) | 83.36 (28.9) | |||
| SES/Parental academic exam, n (%) 1 | 43.8 | 50.0 | 84 | 76.9 | 40.0 | 52.0 | 0.340 |
| Birth length (z-score) | 0.5 (2.1) | –0.7 (1.4) | –0.0 (1.3) | 0.5 (1.3) | –0.2 (1.6) | –0.7 (1.4) | 0.027 |
| Birth length (cm) 2 , mean (SD) | 50.3 (3.9) | 48.1 (2.2) | 49.3 3.6) | 52.1 (1.8) | 51.6 (3.2) | 49.6 (3.0) | |
| Birth weight (z-score) | 0.1 (0.5) | –0.2 (0.5) | –0.1 (0.5) | 0.1 (0.3) | –0.1 (0.5) | –0.2 (0.5) | 0.038 |
| Birth weight (g) 2 , mean (SD) | 3488.5 (797.6) | 2977.5 (653.1) | 3283.0 (681.0) | 3748.1 (363.9) | 3663.0 (752.0) | 3358.1 (745.1) | |
| Gestational week, mean (SD) | 39.1 (2.3) | 38.1 (2.2) | 39.6 (2.0) | 39.8 (2.0) | 40.3 (1.1) | 39.5 (2.3) | 0.683 |
Patients with CAH not treated prenatally with DEX (CAH), patients with CAH treated prenatally with DEX (CAH-DEX) and population controls (C). Children with CAH (not prenatally treated) were born larger than population controls. Statistical analyses for differences between groups were calculated using Fisher’s exact test (two-sided).
Abbreviations: CAH, congenital adrenal hyperplasia; CAH-DEX, CAH who were treated prenatally with DEX; DEX, dexamethasone; HC, hydrocortisone dose; N/A, not applicable; SD, standard deviation; SES, socioeconomic status.
1SES estimated as parental education at university level (%).
2Values not adjusted for gestational age.
3n = 14; 4n = 5; 5n = 14; 6n = 3.