Table 4.
Scores on the Neuropsychological Tests (mean ± 1 SD) for Patients With SW CAH vs Patients With SV CAH
| SW (n = 20) | SV (n = 12) | Cohen’s d | F statistics | P | |
|---|---|---|---|---|---|
| General cognitive ability (estimated IQ) | |||||
| WISC-III Block Design (S) | 10.4 (4.0) | 12.8 (1.1) | -1.25 | 3.97 | 0.058 |
| WISC-III Vocabulary (S) | 11.0 (2.6) | 12.4 (1.3) | -0.57 | 3.50 | 0.073 |
| Executive functions | |||||
| WISC-III Coding (S) | 10.9 (3.1) | 11.2 (1.8) | 0.02 | 0.04 | 0.855 |
| WISC-III Digit Span (S) | 9.5 (3.3) | 10.4 (2.4) | -0.20 | 0.67 | 0.420 |
| Span Board Forward (T) | 50.0 (11.0) | 58.5 (8.9) | -1.20 | 4.72 | 0.039 |
| Span Board Backward (T) | 57.5 (6.7) | 62.5 (7.9) | -1.03 | 4.01 | 0.056 |
| Stroop interference (T) | 53.2 (5.8) | 52.8 (7.5) | 0.01 | 0.02 | 0.898 |
| Learning and long-term memory | |||||
| NEPSY List Learning (S) | 12.2 (1.9) | 11.6 (2.8) | 0.25 | 0.31 | 0.583 |
Effect sizes (Cohen’s d), F statistics and p-values are shown for the entire population (data not split by sex). Positive effect sizes represent higher scores in the SW group, whereas negative effect sizes represent higher scores in the SV group. Patients with SW CAH performed poorer than patients with SV CAH on Span Board Forward.
Scaled scores: population mean = 10 (SD = 3); T-scores: population mean = 50 (SD = 10).
Abbreviations: CAH, congenital adrenal hyperplasia; NEPSY, Developmental Neuropsychological Assessment; SW, salt-wasting; SV, simple-virilizing; S, scaled score; T, T-score; WISC-III, Wechsler Intelligence Scale for Children-III.