Table 5.
Results of Neuropsychological Tests Comparing Female and Male CAH Patients Treated Prenatally With DEX (CAH-DEX) with Female and Male CAH Patients Not Treated Prenatally With DEX (CAH)
| Females | Males | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CAH-DEX (n = 6) | CAH (n = 11) | Cohen’s d | Mann Whitney U test | CAH-DEX (n = 5) | CAH (n = 10) | Cohen’s d | Mann Whitney U test | |||
| U | p | U | p | |||||||
| General intellectual ability (estimated IQ) | ||||||||||
| WISC-III Block Design (S) | 9.2 (3.1) | 9.9 (3.0) | −0.29 | 28.00 | 0.660 | 11.0 (3.4) | 11.0 (3.2) | 0.00 | 21.00 | 0.898 |
| WISC-III Vocabulary (S) | 8.0 (2.7) | 11.4 (2.8) | −1.75 | 12.00 | 0.037 | 11.0 (1.6) | 12.1 (2.0) | −0.86 | 15.00 | 0.254 |
| Executive functions | ||||||||||
| WISC-III Coding (S) | 10.0 (3.0) | 12.1 (3.3) | −0.94 | 18.00 | 0.220 | 11.6 (2.1) | 11.0 (2.2) | −0.40 | 22.00 | 0.768 |
| WISC-III Digit Span (S) | 9.3 (1.9) | 9.4 (2.5) | −0.07 | 32.50 | 0.961 | 8.6 (3.6) | 10.5 (2.1) | −0.90 | 18.00 | 0.440 |
| Span Board Forward (T) | 47.8 (7.5) | 46.5 (9.0) | 0.22 | 25.50 | 0.462 | 49.7 (17.4) | 56.8 (10.1) | −0.70 | 17.00 | 0.733 |
| Span Board Backward (T) | 52.8 (3.4) | 53.4 (8.6) | −0.13 | 28.00 | 0.660 | 49.5 (7.7) | 60.4 (7.4) | −2.04 | 4.00 | 0.024 |
| Stroop interference (T) | 56.0 (6.4) | 55.3 (4.3) | 0.18 | 24.50 | 0.953 | 54.6 (3.3) | 54.8 (9.0) | −0.04 | 23.00 | 0.859 |
| Learning and long-term memory | ||||||||||
| NEPSY List Learning (S) | 10.7 (3.6) | 12.8 (1.8) | −1.05 | 20.50 | 0.216 | 12.0 (2.0) | 11.2 (1.8) | 0.57 | 16.50 | 0.438 |
Scaled scores: population mean = 10 (SD = 3); T-scores: population mean = 50 (SD = 10).
Abbreviations: CAH, congenital adrenal hyperplasia; CAH-DEX, CAH who were treated prenatally with DEX; DEX, dexamethasone; NEPSY, Developmental Neuropsychological Assessment; S, scaled score; T, T-score; WISC–III, Wechsler Intelligence Scale for Children-III.