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. 2020 Jun 15;12(6):2538–2553.

Figure 5.

Figure 5

PAX6 was directly suppressed by miR-129-5p. A. Luciferase reporter assay indicated that PAX6 was directly suppressed by miR-129-5p. B. LINC01619 enhanced PAX6 mRNA expression and miR-129-5p inhibited PAX6 mRNA expression in NSCLC cells. C and D. LINC01619 enhanced PAX6 protein expression and miR-129-5p inhibited PAX6 protein expression in NSCLC cells. E. PAX6 mRNA expression was increased in NSCLC tissues than that in normal tissues. F and G. In NSCLC tissues, PAX6 expression was positively correlated with LINC01619 and negatively correlated with miR-129-5p. H. PAX6 protein expression was increased in 5 pairs of NSCLC tumor tissues (T1, T2, T3, T4 and T5) than that in normal tissues (N1, N2, N3, N4 and N5). I. qRT-PCR and IHC indicated that, patients with advanced TNM stage had higher PAX6 mRNA expression level in their tumor tissues, and more PAX6 positive expression signals were found in tumor tissues (sample I, II and III) than that in normal tissues. **P < 0.01.