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The potential role IDO could play in the pathogenesis of OA disease. As seen, in response As seen in response to cartilage injury proinflammatory cytokines such as IL-1β, TNF-α, and IFN-γ and inflammatory MSCs stimulates DCs to produce IDO1 to rebalance immune status. However, high IDO1 levels produced by DCs and MSCs inhibits chondrogenesis and increase the risk of cartilage erosion by enhancing cartilage inflammations.
