Table 3.
List of the Immune Cells in the Osteoarthritis which have a relation with IDO1 immune activity
| OA-Immune cell | Activity in the OA-Synovial fluid | Reference |
|---|---|---|
| CD19+CD20+ | Low activity | [166] |
| CD3+CD8+ | Low activity | [160,166] |
| T cells/B Cells CD4+/CD8+ | High activity, it could stimulate synovitis by production of proinflammatory cytokines | [152,161,162] |
| CD4+ T Cells/Active Macrophage | Med activity by secretion of TNF-α | [153,154] |
| Treg CD4+CD25+ | High activity, it could contribute to increase TGF-β1 and IL-10 that increase pain and joint stiffness. It increases activated effector memory cells (CD62L-CD69+) | [8,167] |
| CD4+CD25+ Tim-3+ | Significant levels in the OA more than RA that enhance regulatory responses | [155] |
| Macrophage CD68+/B Cell CD20+ | Low expression in the OA synoviits | [161] |
| Macrophage CD68+ | Significantly high in RA but limited increasing in the OA | [164,165] |
| Mast Cells | It was noticed in the OA synovial but with low populations | [64,168] |
| CD56+CD16-/Low cytotoxicity NK Cells/Neutrophils | Recently it was reported but with low numbers | [169,170] |
| plasmacytoid DCs/Myeloid DCs | These cells were significantly noticed in the synovial and bone marrow of OA patients but its function isn’t clear | [45,171] |