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CB-5083 induced cancer cell apoptosis by affecting ER stress. (A-D) mRNA levels of UPR-related genes (BIP, ATF4, CHOP, GADD34, and DNAJB9) in (A) SJSA-1, (B) U2OS, (C) HOS, and (D) MG63 cells treated with CB-5083. (E) Western blotting of UPR-related genes (BIP, XBP1-S, PERK, p-elF2α, and CHOP) in osteosarcoma cells treated with CB-5083.
