Table 3.
Promoter methylation status of NOTCH1, NOTCH2 and NOTCH3 in normal and cancerous biopsies
| Gene | Biopsies | M | UM | M+UM | OR | 95% CI | p-value |
|
| |||||||
| NOTCH1 | Healthy (N=28) | 10 (36%) | 18 (64%) | 0 | 0.05 | 0.02-0.14 | <0.0001 |
| Cancer (N=110) | 101 (92%) | 9 (8%) | 0 | ||||
| NOTCH2 | Healthy (N=28) | 5 (18%) | 23 (82%) | 0 | 0.4 | 0.16-1.1 | 0.11 |
| Cancer (N=110) | 39 (36%) | 71 (65%) | 0 | ||||
| NOTCH3 | Healthy (N=28) | 4 (14%) | 17 (61%) | 7 (25%) | 0.15 | 0.05-0.46 | 0.001* |
| Cancer (N=110) | 67 (61%) | 43 (39%) | 0 | ||||
|
| |||||||
| Gene | Biopsies | M | UM | M+UM | OR | 95% CI | p-value |
|
| |||||||
| NOTCH1 | Healthy (N=28) | 10 (36%) | 18 (64%) | 0 | 0.05 | 0.02-0.14 | <0.0001 |
| Cancer (N=110) | 101 (92%) | 9 (8%) | 0 | ||||
| NOTCH2 | Healthy (N=28) | 5 (18%) | 23 (82%) | 0 | 0.4 | 0.16-1.1 | 0.11 |
| Cancer (N=110) | 39 (36%) | 71 (65%) | 0 | ||||
| NOTCH3 | Healthy (N=28) | 4 (14%) | 17 (61%) | 7 (25%) | 0.15 | 0.05-0.46 | 0.001* |
| Cancer (N=110) | 67 (61%) | 43 (39%) | 0 | ||||
M: Methylated; UM: Un-methylated; OR: Odds ratio; CI: Confidence of interval; N: Number;
*
Significant at P≤0.05.