Table 4.

Relationship between promoter hypermethylation of NOTCH1, NOTCH2 and NOTCH3 and clinicopathological features

Clinico-pathological Factors	Total (110)	Methylation status of NOTCH1		OR (95% CI)	p-value	Methylation status of NOTCH2		OR (95% CI)	p-value	Methylation status of NOTCH3		OR (95% CI)	p-value
		M (101)	UM (9)			M (39)	UM (71)			M (67)	UM (43)
Age
<55 years	42	35 (83%)	7 (17%)	0.15 (.03-0.8)	0.03*	28 (67%)	14 (33%)	11 (4.3-24)	0.0001*	21 (50%)	21 (50%)	0.48 (0.22-1.1)	0.07
≥55 years	68	66 (97%)	2 (3%)			11 (16%)	57 (84%)			46 (68%)	22 (32%)
Menopause
Pre	43	40 (93%)	3 (7%)	1.3 (.3-5.5)	1	8 (19%)	35 (81%)	0.3 (0.1-0.6)	0.004*	20 (47%)	23 (53%)	0.37 (0.17-0.82)	0.016*
Post	67	61 (91%)	6 (9%)			31 (46%)	36 (54%)			47 (70%)	20 (30%)
Histological grading
Cervicitis & SCC	106	99 (93%)	7 (7%)	14 (1.9-95)	0.03*	37 (35%)	69 (65%)	0.54 (0.07-4)	0.61	64 (60%)	42 (40%)	0.5 (.04-3.5)	0.9
ADC & ASC	4	2 (50%)	2 (50%)			2 (50%)	2 (50%)			3 (75%)	1 (25%)
Differentiation degree*
Poor	8	8 (100%)	0	Infinity	0.05*	3 (38%)	5 (63%)	1.3 (0.3-5.8)	1	4 (50)	4 (50)	1.7 (0.4-6.1)	0.7
Well & Moderate	56	36 (64%)	20 (36%)			18 (32%)	38 (68%)			21 (38)	35 (63)

M: Methylated; UM: Unmethylated; SCC: Squamous Cell Carcinoma; ADC: Adenocarcinoma; ASC: Adenosquamous Carcinoma; OR: Odd ratio; CI: Confidence of interval;

^*Significant at P≤0.05.