Table 5.
Correlation of HPV infection with NOTCH1, NOTCH2 and NOTCH3 methylation in cervical cancer
| HPV Type | N (110) | Methylation status of NOTCH1 | OR (95% CI) | p-value | Methylation status of NOTCH2 | OR (95% CI) | p-value | Methylation status of NOTCH3 | OR (95% CI) | p-value | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|||||||||||
| M (101) | UM (9) | M (39) | UM (71) | M (67) | UM (43) | ||||||||
| HPV16+ | 90 | 87 (97%) | 3 (3%) | 15.6 (3.4-59) | 0.003* | 28 (31%) | 62 (69%) | 0.4 (0.14-1) | 0.04* | 60 (67%) | 30 (33%) | 3.7 (1.3-9.4) | 0.011* |
| HPV18+ | 78 | 73 (94%) | 5 (6%) | 2.1 (0.6-7.7) | 0.012* | 18 (23%) | 60 (77%) | 0.2 (.06-0.4) | 0.001* | 44 (56%) | 34 (44%) | 0.5 (0.2-1.1) | 0.19 |
| HPV16+ & 18+ | 60 | 58 (97%) | 2 (3%) | 4.7 (0.9-23) | 0.07 | 18 (30%) | 42 (70%) | 0.6 (0.3-1.3) | 0.2 | 40 (67%) | 20 (33%) | 1.7 (0.8-3.8) | 0.2 |
N: Number; HPV: Human Papillomavirus; M: Methylated; UM: Unmethylated; OR: Odd Ratio; CI: Confidence of interval;
*
Significant at P≤0.05.