TABLE 2.
Genetic variations in Cytochrome P450 and human leucocyte antigen genes that are associated with ART induced adverse reactions
| Gene | Genotype/allele | Drugs | Adverse reaction | Reference |
|---|---|---|---|---|
| CYP2B6 | 6/6 | Nevirapine, efavirenz | DILI, hypersensitivity | 69, 71, 105 |
| HLA‐DRB1 | 0101 | Nevirapine | DILI, hypersensitivity | 78, 83 |
| HLA‐DRB1 | 0102 | Nevirapine | DILI | 79 |
| HLA‐B | 5701 | Abacavir | Hypersensitivity | 75, 80, 81 |
| HLA‐B | 3505 | Nevirapine | Hypersensitivity | 84, 85 |
| HLA‐B | 5801 | Nevirapine | DILI | 79 |
| HLA‐C | 0401 | Nevirapine | Hypersensitivity | 85, 86 |
Abbreviations: ART, antiretroviral therapy; DILI, drug‐induced liver injury.