Figure 1.

Study design. After seven days of adaptation, the antibiotic (AB) group was given ceftriaxone and the control (CT) group was given saline by gavage once a day. The open-field test (OFT) and tail-suspension test (TST) were given to mice once a week. After 11 weeks of oral gavage, significant behavioral differences were noted between the groups. On the second day after the last behavioral experiment was performed, mice were administered the final gavage exposure, and 1 h later, fresh blood and stool was sampled.