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. 2020 Jun 29;11:1342. doi: 10.3389/fimmu.2020.01342

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Copyright © 2020 Wilhelmson, Lantero Rodriguez, Johansson, Svedlund Eriksson, Stubelius, Lindgren, Fagman, Fink, Carlsten, Ekwall and Tivesten.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TEC shift in E-ARKO mice. (A) Gating strategy for TECs. (B–D) Relative numbers of all thymic epithelial cells (TECs), cortical (cTEC; CD45⁻ EpCAM⁺ UEA1⁻ Ly51⁺), and medullary (mTEC; CD45⁻ EpCAM⁺ UEA1⁺ Ly51⁻) TEC in control and E-ARKO male mice; n = 8/group. (E) Assessment of AR knockout by measurement of exon 2 gDNA in mTECs from 4-week-old control (K5-Cre⁺; n = 4) and E-ARKO (AR^flK5-Cre⁺; n = 4) male mice. (F) Assessment of AR knockout by measurement of exon 2 gDNA in cTECs from 8-week-old control (K5-Cre⁺; n = 4 pools, 2 mice/pool) and E-ARKO (AR^flK5-Cre⁺; n = 6 pools, 2 mice/pool) male mice. ^*P < 0.05 (Mann-Whitney U test); all bars indicate means; circles represent individual mice, error bars indicate SEM.