TABLE 1.

Alterations in GABA levels and GABAergic interneurons in AD patients.

Subtypes	Age (Years)	Subregion	Number	References
GABA level	65.73 ± 8.53	Parietal region	↓	Bai et al., 2015
GABA level	62.3 ± 6.7	CSF	↓	Bareggi et al., 1982
SST level	78–97	Frontal cortex	↓	Grouselle et al., 1998
GABA level	73.8 ± 8.4	CSF	↓	Zimmer et al., 1984
SOM(SST)–neurons	72.3 ± 2.3	Frontal and temporal lobes	↓	Beal et al., 1985, 1986
	82	Frontal and temporal lobes	↓	Candy et al., 1985
	74	Frontal and temporal lobes	↓	Davies et al., 1980; Davies and Terry, 1981
PV neurons	75–86	Neocortex	Unchanged	Ferrer et al., 1991
	81.0 ± 6.1	Neocortex	Unchanged	Hof et al., 1991
	81.2 ± 2	DG/CA1-2	↓	Brady and Mufson, 1997
	58–92	EC	↓	Solodkin et al., 1996
SOM(SST)–neurons	63–100	Olfactory tubercle and piriform cortex	↓	Mikkonen et al., 1999; Saiz-Sanchez et al., 2016
PV neurons			↓
CR neurons		Amygdala and EC	↓
PV neurons	86.4 ± 2.2	DG	Unchanged	Takahashi et al., 2010
CR neurons		DG	↓
SOM(SST)	75.3 ± 13.9	Perirhinal cortex	↓	Saiz-Sanchez et al., 2013
PV neurons			↓
GABABR1–neurons	77.8 ± 13.9	CA1	Significantly reduced↓	Iwakiri et al., 2005
GABABR1–immunoreactivity		CA4 and CA2/3	Increased