TABLE 2.

Alterations in specific subtypes of GABA interneuron in typical AD mouse models.

Model	Subtypes	Age (M)	Subregion	Number	Activity	References
hAPP-J20	PV/CR neurons	8 M	GABAergic SHP	Unchanged, but axons are decreased	↓ Hippocampal θ and γ oscillations are diminished	Rubio et al., 2012
	Unclassified	3 M	CA1	↓		Wright et al., 2013
			CA3	Unchanged
	PV neurons	3 M/4 M–7 M	Parietal cortex	Unchanged	↓ Nav1.1 and γ oscillations are decreased	Verret et al., 2012; Martinez-Losa et al., 2018
3×Tg	PV neurons	18 M	CA1	52%↓	PV expression is decreased	Zallo et al., 2018
	CR neurons	18 M	CA1	33.7%↓	Unchanged CR expression
APP/PS1h-o	PV neurons	10 M	CA1-2	↓		Takahashi et al., 2010
KI	CR neurons	10 M	DG and hilus	↓
AβPPswe/PS1-dE9	PV neurons	6 M/8 M	Olfactory cortex	↓	A later and less pronounced decrease	Saiz-Sanchez et al., 2012
	CR neurons	2/4/6/8 M	Olfactory cortex	↓
	SST neurons	4/6/8 M	Olfactory cortex	↓	Both CR and SST: an early and marked fall
APP/PS1-KI	PV neurons	10 M	Frontal cortex	Unchanged		Lemmens et al., 2011
	CR neurons	10 M		Unchanged
APP751Swed	PV neurons	6 M	Perirhinal cortex	Unchanged		Sanchez-Mejias et al., 2019
Lond/PS1M146L	SOM neurons			↓
APPswe/PS1-dE9	PV neurons	3 M/12 M	CA3	↑		Verdaguer et al., 2015
	CR neurons	3 M/12 M	SGZ	↓
	CR neurons	12 M	Hilus	↑
	PV neurons	4 M	Hippocampus		↑	Hijazi et al., 2019
TgCRND8	NPY neurons	5,6 M	Hippocampus	↓		Ma and McLaurin, 2014, 2017
	SST neurons	5,6 M	Hippocampus	↓
AppNL–/NL–F	PV neurons	10–18 M	Dorsal LEC	↓	A reduction in the somatic inhibitory axon terminal	Petrache et al., 2019
	CR neurons	4–18 M	CA1	Unchanged		Shi et al., 2019
	CCK neurons	4–18 M	CA1	↓
	SST neurons	9–18 M	CA1	↓
5×FAD	PV neurons	12 M	Cortex layer IV	28.9%↓		Flanigan et al., 2014
	PV neurons	3 M	CA1/CA3		γ oscillations decreased↓	Iaccarino et al., 2016
		6 M	Auditory cortex CA1/mPFC		↓	Martorell et al., 2019
Tg2576	PV neurons	6 M	EC	Dendritic branch spines ↓	↓	Shu et al., 2016; Yang et al., 2018
	PV neurons	3 M	CA1-3		↓	Cattaud et al., 2018
	PV neurons	6–19 M	CA1/CA3	↓		Huh et al., 2016
Mutated Tau VLW line	PV neurons	2 M/8 M	GABAergic SHP	Unchanged, but axon terminals are decreased	↓	Soler et al., 2017
PS1M146L× AβPP 751SL	SOM neurons	6 M	Hippocampus	A profound ↓ diminution (50–60%)		Ramos et al., 2006
	CR neurons	4–12 M	CA1 and CA2/3	A substantial ↓ decrease (35–45%)		Baglietto-Vargas et al., 2010
APP695swe/PS1-dE9	PV neurons	4 M	Frontal cortex	A significant ↓ reduction (20%)		Cheng et al., 2019
	CR neurons	4 M	Frontal cortex	A decreased tendency
Sirt3+/– /APP695swe/PS1-dE9	PV and CR neurons	4 M	Frontal cortex	Significantly ↓ reduced by more than 50%
Tau P301S and CK-p25	PV neurons	6 M	Visual cortex, prefrontal cortex, and CA1		γ oscillations are decreased ↓	Adaikkan et al., 2019
ApoE4-KI	SST neurons	6–21 M	Hilus	↓		Andrews-Zwilling et al., 2010

↓Number: significantly decreased; Activity: significantly downregulated.