Table 2.

Comparison of animal models for atherosclerosis.

	Mouse	Zebrafish		Rat (57, 85–87)	Rabbit (88–92)
		Larvae	Adult
ApoE−/−	✓	X		✓	✓
Ldlr−/−	✓	✓		✓	✓
Apoc2−/−	✓	✓		X	X
lcat	✓	✓		✓	✓
cetp	X	✓		X	✓
Maturation	2 months	3 months		2–3 months	5–6 months
Progeny	5–8	200–300		Ø10	4–12
Transparency	X	✓	X	X	X
Housing	Group (6–10)	Swarm (4–10/L)		Group (2–4)	Group (2–8)
Dominating the lipoprotein profile	LDL	HDL		LDL	VLDL and LDL
Cholesterol transport	HDL	HDL		HDL	HDL
Vitamin C synthesis	✓	X		✓	✓
Favored source of energy	Carbohydrates	Lipid		Carbohydrates	Carbohydrates
Collection of blood samples	Non-lethal	None from individuals; lethal	Mostly lethal	Non-lethal	Non-lethal
Intima thickening	✓	X	✓	✓	✓
Lesions	Aorta and carotids	Caudal vein	Dorsal aorta	Aorta	Aorta and carotids
Lesion rupture	Rarely	X		X	Rarely
Highest atherosclerotic classification	Type V to type VI rupture	Type II fatty streak		Type III	Type V to type VI rupture
Oxygenated cholesteryl esters	In atherosclerotic lesions	In body liquids		In atherosclerotic lesions	In atherosclerotic lesions