TABLE 4.
Key differentially expressed proteins identified by tandem mass tag-based proteomics analysis between PD patients and healthy controls.
| Uniprot ID | Protein name (GeneName) | MW [kDa] | FC valuea | p-valueb |
| O75339 | Cartilage intermediate layer protein 1 (CILP) | 132.48 | 1.247 | 0.003 |
| A9UFC0 | Caspase 14 (CASP14) | 27.65 | 2.077 | 0.010 |
| Q5T619 | Zinc finger protein 648 (ZNF648) | 62.30 | 1.276 | 0.010 |
| Q04756 | Hepatocyte growth factor activator (HGFAC) | 70.64 | 1.605 | 0.013 |
| Q9UQ05 | Potassium voltage-gated channel subfamily H member 4 (KCNH4) | 111.62 | 1.213 | 0.014 |
| E5RIF9 | Carbonic anhydrase 1 (CA1) | 16.31 | 1.230 | 0.021 |
| P01023 | Alpha-2-macroglobulin (A2M) | 163.19 | 1.251 | 0.025 |
| B7Z544 | cDNA FLJ51742, highly similar to Inter-alpha-trypsin inhibitor heavy chain H4 | 98.29 | 1.206 | 0.026 |
| Q6UWP8 | Suprabasin (SBSN) | 60.50 | 1.230 | 0.028 |
| A0A087WYF1 | Laminin subunit alpha-2 (LAMA2) | 343.20 | 1.254 | 0.030 |
| P04275 | von Willebrand factor (VWF) | 309.06 | 1.210 | 0.031 |
| D3DQX7 | Serum amyloid A protein (SAA1) | 13.55 | 1.264 | 0.032 |
| A0A125U0U7 | MS-C1 heavy chain variable region | 13.09 | 1.210 | 0.039 |
| Q96K23 | cDNA FLJ14838 fis, clone OVARC1001726, weakly similar to APICAL-LIKE PROTEIN | 27.99 | 1.380 | 0.041 |
| D6RF20 | Vitamin D-binding protein(GC) | 16.07 | 1.255 | 0.046 |
| P02656 | Apolipoprotein C-III (APOC3) | 10.85 | 0.718 | 0.001 |
| Q1W658 | Follicle-stimulating hormone beta subunit (FSHB) | 8.45 | 0.331 | 0.002 |
| K7ER74 | Protein APOC4-APOC2 (APOC4-APOC2) | 20.04 | 0.661 | 0.002 |
| Q04695 | Keratin, type I cytoskeletal 17 (KRT17) | 48.08 | 0.465 | 0.003 |
| Q5NV68 | V4-1 protein (V4-1) | 11.23 | 0.342 | 0.005 |
| Q59HB3 | Apolipoprotein B variant | 183.46 | 0.832 | 0.007 |
| P04259 | Keratin, type II cytoskeletal 6B (KRT6B) | 60.03 | 0.611 | 0.008 |
| K7ERI9 | Apolipoprotein C-I (APOC1) | 8.64 | 0.710 | 0.009 |
| G5E968 | Chromogranin A (CHGA) | 34.25 | 0.786 | 0.009 |
| Q99592 | Zinc finger and BTB domain-containing protein 18 (ZBTB18) | 58.32 | 0.830 | 0.009 |
| P10720 | Platelet factor 4 variant (PF4V1) | 11.55 | 0.778 | 0.010 |
| O95445 | Apolipoprotein M (APOM) | 21.24 | 0.831 | 0.011 |
| A0A0G2JPR0 | Complement C4-A (C4A) | 192.75 | 0.620 | 0.012 |
| Q99857 | Tenascin-C | 9.76 | 0.818 | 0.013 |
| Q07507 | Dermatopontin (DPT) | 23.99 | 0.724 | 0.015 |
| O95576 | Pepsinogen | 8.71 | 0.820 | 0.015 |
| C0KRQ8 | Glycoprotein hormones alpha chain (CGA) | 10.20 | 0.542 | 0.016 |
| P55056 | Apolipoprotein C-IV (APOC4) | 14.54 | 0.817 | 0.020 |
| P35908 | Keratin, type II cytoskeletal 2 epidermal (KRT2) | 65.39 | 0.827 | 0.033 |
| E1B4S7 | Apolipoprotein B (APOB) | 25.22 | 0.831 | 0.034 |
| P80108 | Phosphatidylinositol-glycan-specific phospholipase D (GPLD1) | 92.28 | 0.785 | 0.034 |
| H7C0N0 | Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) | 51.83 | 0.811 | 0.039 |
| H7BZ76 | Latent-transforming growth factor beta-binding protein 1 (LTBP1) | 28.80 | 0.806 | 0.040 |
| Q7RTS7 | Keratin, type II cytoskeletal 74 (KRT74) | 57.83 | 0.807 | 0.040 |
| B2RCB8 | cDNA, FLJ95971, highly similar to Homo sapiens protocadherin 12 (PCDH12) | 128.91 | 0.819 | 0.044 |
aFC value was calculated as the ratio of the average mass response (area) between the two groups (FC value = PD/HC). Thus, FC values >1 indicate significantly higher levels in the PD group relative to the HC group while FC values <1 indicate significantly lower levels in the PD group. bOnly proteins with FC values greater than ± 1.2 and p-values less than 0.05 were deemed statistically significant. PD, Parkinson’s disease; MW, molecular weight; FC, fold change; HC, healthy control.