Figure 2.

Core clock mechanism in the context of epilepsy. The core clock mechanism consists of three main feedback loops, which are thought to involve PER/CRY, REV-ERB/ROR, and DBP/NFIL3, respectively. Key proteins involved in these loops, whose levels fluctuate over the course of the day, are thought to also influence the expression of genes involved in seizure susceptibility or epileptic processes. Green arrows represent transcriptional activation, whereas red lines represent transcriptional repression. Rectangles represent genes and other DNA sequences of note, whereas ovals represent proteins. For a more comprehensive review on the processes underlying the molecular clock, please refer to (59) [Figure modified from (59)].