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. 2020 Jun 29;10:1025. doi: 10.3389/fonc.2020.01025

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Copyright © 2020 Zhang, Zhou, Xiao, Li, Guo, Wang, Yu and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reduction of KDM5C expression is correlated with poor prognosis in ICC. (A) qRT-PCR assay of KDM5C mRNA expression in 18 paired groups of specimens of human ICC and non-tumor adjacent tissues. (B) Comparison of the expression of KDM5C mRNA in human ICC and adjacent non-tumor liver tissues. The mRNA level of KDM5C was significantly downregulated in ICC tissues. (C) Western blot analyses of KDM5C in human ICC and adjacent non-tumor liver tissues. (D) Immunohistochemical patterns of KDM5C of human ICC specimens. Scale bars, 50 μm (upper) and 20 μm (lower). (E,F) Kaplan-Meier survival analysis of the overall survival (E) and disease-free survival (F) of ICC patients which were divided into two different groups according to the protein levels of KDM5C, which were determined by immunohistochemical assay. Data are presented as the mean ± SD. ***p < 0.001. All results are from three independent experiment.