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. 2020 Jun 29;10:1025. doi: 10.3389/fonc.2020.01025

Figure 4.

Figure 4

FASN represents the major target gene of KDM5C to regulate cell proliferation and invasion. (A) Western blotting assay of FASN and KDM5C protein of FASN and/or KDM5C overexpression experiments in CCLP1 and HCCC9810 cells. (B) Oxygen consumption rates (OCR) were measured after restoration of the expression of FASN in control or KDM5C-overexpressed cells. (C) Colony formation and mean number of colonies after restoration of the expression of FASN in control or KDM5C-overexpressed cells. (D) Quantification of invaded cells after restoration of the expression of FASN in control or KDM5C-overexpressed cells were shown. Scale bars, 100 μm. Data are presented as the mean ± SD. *p < 0.05, **p < 0.01, ***p < 0.001. All results are from three independent experiments.