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. 2020 Jun 23;11:593. doi: 10.3389/fphys.2020.00593

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Copyright © 2020 Zhang, Zhang, Li, Ren, Deng, Yin, Gao, Pan and Niu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pulp regeneration in vivo. Macroscopic view of the root segment (A). Root segments with collagen I alone did not contain any tissue (B,C). hUCMSCs alone in collagen I revealed loosely arranged connective tissue (D,E). Significantly increased extracellular matrix deposition was observed in the hUCMSC and VEGF-induced hUCMSC (V-hUCMSCs) groups (F,G). The hUCMSC and V-hUCMSC cocultured groups exhibited an angiogenesis tendency (G,I,K, arrows). There was no angiogenesis in hUCMSCs alone group (H,J).