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. 2020 Jun 30;8:745. doi: 10.3389/fbioe.2020.00745

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Copyright © 2020 Tang, Zhou, Li, Wang, Liu, Wang, Liu and Ye.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Schematic description of the evaluation of ex vivo degenerative IVD tissue and treatment with HGC hydrogel for CT and MRI imaging. (B) Macroscopic observation and micro-CT images of degenerated IVD tissue at 1 day and 28 days after injection with hydrogels. (C) MRI images of IVD tissue before and 2 weeks after the disk degeneration process and subsequent degenerative IVD tissue at 2 weeks and 5 weeks after injection of HGC hydrogel in 30% alcohol solution. Reproduced from Li et al. (2018) with permission from Copyright 2018 Elsevier.