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Adrenergic control of circadian leukocyte trafficking to skeletal muscle. During the night (in mice), adrenergic signals from sympathetic neurons drive upregulation of adhesion molecule, ICAM-1, on blood endothelial cells in skeletal muscle. This promotes leukocyte trafficking to and extravasation into tissue during the night, while reduced ICAM-1 expression during the day facilitates return to circulation.
