TABLE 1.

Cox proportional hazards regression model showing the association of variables with overall survival.

Variables		Patient N = 335	Univariate analysis			Multivariate analysis
			HR	95% CI	P	HR	95% CI	P
Age	≤65	152	Reference			Reference
	>65	183	1.815	1.010–3.261	0.046	1.944	1.074–3.518	0.028
Gender	Male	162	Reference
	Female	173	1.013	0.775–1.324	0.924
Tumor location	Right	147	Reference
	Left	188	0.967	0.566–1.652	0.903
Tumor recurrence	No	261	Reference
	Yes	74	0.740	0.348–1.572	0.434
Neoplasm cancer	Tumor free	153	Reference
	With tumor	182	0.924	0.541–1.578	0.771
Residual tumor	R0	280	Reference
	R1 + R2	55	2.948	1.693- 5.133	<0.001
Tumor stage	I	58	Reference
	II	125	1.209	0.331–4.410	0.774
	III	102	3.149	0.932–10.647	0.065
	IV	50	7.806	2.325–26.207	0.001
T stage	T1	12	Reference
	T2	57	0.644	0.067–6.192	0.703
	T3	233	1.827	0.250–13.320	0.522
	T4	33	4.379	0.554–37.600	0.161
N stage	N0	188	Reference			Reference
	N1	88	2.498	1.259–4.958	0.009	2.771	1.331–5.766	0.006
	N2	59	4.923	2.522–9.609	<0.001	4.116	1.960–8.643	<0.001
M stage	M0	285	Reference			Reference
	M1	50	4.178	2.413–7.234	<0.001	3.280	1.791–6.005	<0.001
lncRNA risk	Low	168	Reference			Reference
	High	167	4.004	2.100–7.633	<0.001	4.900	2.485–9.662	<0.001
miRNA risk	Low	168	Reference			Reference
	High	167	1.853	1.370–2.506	<0.001	4.027	2.155–7.524	<0.001
mRNA risk	Low	168	Reference
	High	167	1.670	1.239–2.251	0.001

HR, hazard ratio; CI, confidence interval.