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. Author manuscript; available in PMC: 2021 Mar 12.
Published in final edited form as: J Med Chem. 2019 Dec 16;63(5):2372–2390. doi: 10.1021/acs.jmedchem.9b01287

Scheme 5. a Synthesis of analogues of compound (S)-17.

Scheme 5.

a Reagents and conditions: (a) 52, 11-phenylundecanoic acid, or palmitoleic acid, DCC, DMAP, DCM, rt, 5 h, 55–96%; (b) oleoyl chloride, pyridine, DCM, rt, 18 h, 15%; (c) H2, 10% Pd/C, EtOH, rt, 72–80%; (d) TFA, DCM, rt, 5 h, 81–93%.