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RAP normalized Dex-Ace-induced ultrastructural changes of mitochondria at 4 weeks. In the Dex-Ace-treated group (A, B), the mitochondria were swollen and deformed, mitochondrial crests disappeared, and autophagic mitochondria fused into huge autophagosomes. In the Dex-Ace+RAP-treated group (C, D), the mitochondria maintained normal shape and arrangement, and the mitochondrial membrane and crests were clearly visible. (arrows indicate mitochondrial; n=5; magnification: 5,000×).
