Table 3.

Strategies to improve therapeutic efficacy for IPN treatment

Type	Category	Strategy
Viral delivery	Toxicity	Reduction of genotoxicity using specific target sequence to avoid activation of proto-oncogene or using regulatory machinery for transgene expression
	Efficiency	Enhancement of viral tropism specific to peripheral nervous system
Non-viral delivery	Stability	Development of enhanced vehicle to increase the stability of oligonucleotides
		Chemical modification of oligonucleotide to increase the stability
	Efficiency	Development of novel chemical composition or peptide to enhance cell uptake and to facilitate endolysosomal escape or nuclear translocation
	Specificity	Isolation of novel receptors or membrane compositions in Schwann cell or axon
		Development of novel ligands specific to peripheral nervous system