Figure 1.

Example of a patient referred for ¹⁸F-NaF PET/low-dose CT (ldCT) for primary staging. An inconclusive lesion (red arrow) with increased uptake on ¹⁸F-NaF PET/ldCT is noticed in Th12 on maximum intensity projection (MIP) (a) and in fused axial projection (b). No correlating lesion is observed on ldCT (c). Subsequent ⁶⁸Ga-PSMA PET/CT showed increased uptake (d,e). Nevertheless, there was no visible lesion on CT (f). Five months later, an additional ¹⁸F-NaF PET/CT scan showed increased uptake (g,h). A sclerotic lesion was visible on CT by that time (i). Several lymph node metastases and lung metastases are noticed on the PSMA MIP (d).