Table 2.
Profile and factors associated with incident TB among household contacts of patients with pre-XDR and XDR tuberculosis in Mumbai, India, January 2016–June 2018 (N = 400). * Column percentage; ** Row percentage; N(%) were compared using the Chi-square test or Fisher’s exact test; †: Median (Inter-quartile range), compared using the Wilcoxon rank-sum test; Pre-XDR TB: Pre-extensive drug resistant TB; XDR-TB: Extensive drug-resistant TB; PTB = Pulmonary TB; EPTB = Extra-Pulmonary Tuberculosis; AFB = Acid fast bacilli.
| Variable | Household Contacts (n = 400) * | Household Contacts with Incident TB(n = 14) ** | p-Value | |
|---|---|---|---|---|
| Index Case Characteristics | n (%) | n (%) | ||
| Type of index case | Pre-XDR | 166 (41) | 7 (4) | 0.51 |
| XDR | 234 (59) | 7 (3) | ||
| Age (Median(IQR), years) † | 24 (19–30) | 24 (18–26) | 0.43 | |
| Sex | Male | 156 (39) | 6 (4) | 0.76 |
| Female | 244 (61) | 8 (3) | ||
| Prior TB treatment | No treatment | 23 (6) | 2 (9) | 0.43 |
| TB treatment | 377 (94) | 12 (3) | ||
| HIV in index case | No | 384 (96) | 12 (3) | 0.10 |
| Yes | 16 (4) | 2 (13) | ||
| AFB result | Negative | 183 (47) | 8 (4) | 0.59 |
| Scanty | 42 (11) | 2 (5) | ||
| Positive | 162 (42) | 4 (3) | ||
| Site of TB | EPTB | 51 (13) | 0 (0) | |
| PTB | 349 (87) | 14 (4) | ||
| X-ray results | Abnormal | 344 (88) | 14 (4) | |
| Normal | 47 (12) | 0 (0) | ||
| Number of household contacts † | 6 (4–8) | 6 (5–10) | 0.21 | |
| Household Contact Characteristics | ||||
| Age group | 0–14 years | 94 (23) | 4 (4) | 0.75 |
| 15 years or more | 306 (97) | 10 (3) | ||
| Sex | Male | 205 (51) | 6 (3) | 0.52 |
| Female | 195 (49) | 8 (4) | ||
| Relationship with index case | Child | 68 (17) | 3 (4) | 0.37 |
| Parent | 120 (30) | 4 (3) | ||
| Sibling | 97 (24) | 6 (6) | ||
| Spouse | 22 (6) | 0 (0) | ||
| Other | 93 (23) | 1 (1) | ||
| Area < 50 sq/feet/capita | No | 226 (59) | 10 (4) | 0.32 |
| Yes | 159 (41) | 4 (3) | ||
| Past history of TB | No | 358 (90) | 11 (3) | 0.17 |
| Yes | 42 (10) | 3 (7) | ||