Figure 1.

Schematic diagram of the multilayered microfluidic chip for modeling pharmacokinetic (PK) profiles of drug administration. (a) The concentration-time curve in vivo. (b) The actual image of the multilayered chip. (c) The configuration of the chip device. The device is composed of three layers, including the S-shaped upper channel loading with intestine cells, porous membrane, and bottom channel loading with targeted cells. (d) Schematic view of the PK process of absorption and excretion on cells with drug exposure in the device.