Table 4.
Cell Lines and Virus | MRC-5 a | Vero 76 b | EVA71 |
---|---|---|---|
CC50 c | EC50 d | ||
Leaves oil | 100 | 80 | >80 |
Rhizomes oil | >100 | >100 | >100 |
Whole-plant oil | >100 | >100 | >100 |
Rupintrivir e | 0.07 |
Data represent mean values ± SD for three independent determinations. For values where SD is not shown, variation among triplicate samples was less than 15%. a Normal human lung fibroblast; b Monkey kidney; c Compound concentration (µg/mL) required to reduce cell proliferation by 50%, as determined by the MTT method; d Compound concentration (µg/mL) required to reduce the plaque number of EV-A71 by 50% in Vero-76 monolayers; e Reference compound: EC50 is in µM.