Table 4.
Cytotoxicity and antiviral activity of EOs from leaves and rhizomes of H. bella against selected cell lines and Enterovirus A71 (EVA71).
| Cell Lines and Virus | MRC-5 a | Vero 76 b | EVA71 |
|---|---|---|---|
| CC50 c | EC50 d | ||
| Leaves oil | 100 | 80 | >80 |
| Rhizomes oil | >100 | >100 | >100 |
| Whole-plant oil | >100 | >100 | >100 |
| Rupintrivir e | 0.07 | ||
Data represent mean values ± SD for three independent determinations. For values where SD is not shown, variation among triplicate samples was less than 15%. a Normal human lung fibroblast; b Monkey kidney; c Compound concentration (µg/mL) required to reduce cell proliferation by 50%, as determined by the MTT method; d Compound concentration (µg/mL) required to reduce the plaque number of EV-A71 by 50% in Vero-76 monolayers; e Reference compound: EC50 is in µM.