Table 1.

Summary of cases with or without cardiovascular defects in Tgfb3 knockout mice (Embryonic Day 13.5 to 18.5; n = 19).

ID#	Genotype	Age	DORV	AV Thickening	PV Thickening	Vascular walls Abnormalities	VSD	AVSD	Thin Myocardium	RV Hyperplasia	MV Thickening	TV Thickening
KO1	Tgfb3 −/−	e16.5-17.5	No	No	No	No	No	No	No	No	No	No
KO2	Tgfb3 −/−	e13.5	No	Yes	Yes	No	Perimembranous	No	Yes	No	Yes	Yes
KO3	Tgfb3 −/−	e14.5-15.5	No	No	No	No	No	No	No	No	Yes	Yes
KO4	Tgfb3 −/−	e14.5-15.5	No	Yes	Yes	No	Muscular	No	No	No	Yes	Yes
KO5	Tgfb3 −/−	e14.5-15.5	No	Yes	Yes	No	Muscular	No	Yes	No	No	No
KO6	Tgfb3 −/−	e14.5-15.5	No	No	No	No	No	No	No	No	No	No
KO7	Tgfb3 −/−	e14.5-15.5	No	No	No	No	No	No	No	No	No	No
KO8	Tgfb3 −/−	e16.5-17.5	No	No	No	No	No	No	No	No	No	No
KO9	Tgfb3 −/−	e13.5	No	Yes	Yes	No	Perimembranous	No	No	Yes	Yes	Yes
KO10	Tgfb3 −/−	e16.5-17.5	No	Yes	Yes	No	No	No	No	No	No	No
KO11	Tgfb3 −/−	e14.5-15.5	No	Yes	Yes	ND	No	No	No	Yes	Yes	Yes
KO12	Tgfb3 −/−	e18.5	No	Yes	Yes	Yes	No	No	Yes	No	No	No
KO13	Tgfb3 −/−	e18.5	No	Yes	Yes	Yes	Perimembranous	No	No	Yes	No	No
KO14	Tgfb3 −/−	e15.5-16.5	No	Yes	Yes	No	No	No	Yes	No	No	No
KO15	Tgfb3 −/−	e15.5-16.5	Subaortic	Yes	Yes	Yes	Perimembranous	No	No	Yes	Yes	Yes
KO16	Tgfb3 −/−	E18.5	No	No	No	No	No	No	No	No	No	No
KO17	Tgfb3 −/−	e13.5	No	Yes	Yes	No	No	No	No	No	Yes	Yes
KO18	Tgfb3 −/−	e14.5	No	No	No	No	No	No	No	No	No	No
KO19	Tgfb3 −/−	e13.5	No	Yes	Yes	No	Muscular	No	Yes	No	Yes	Yes
	Number of cases (%)		1 (5.2%)	12 (63.15%)	12 (63.15%)	3 (15.7%)	P: 4 (21%); M: 3 (15.7%)	0 (0%)	6 (31.5%)	4 (21%)	8 (42.1%)	8 (42.1%)
Total cases	Tgfb3 −/−	19
Total cases	Wildtype (Tgfb3+/+)	14

Abbreviations: DORV, double outlet right ventricle; AV, atrioventricular valve; PV, pulmonary valve; VSD, ventricular septal defect; AVSD, atrioventricular septal defect; RV, right ventricule; MV, mitral valve; TV, tricuspid valve.