Table 1.

Plant-derived terpenes in clinical trials (CT). Includes Not yet recruiting, Recruiting, Enrolling by invitation, Active not recruiting, Suspended and Completed trials of these compounds, parent extracts, or derivatives, applied alone or as a mixture with other constituents. Determined from www.clinicaltrials.gov on 14 May 2020.

Compound	Plant Source	Number of CT	Medicinal Purposes	Ref.
Andrographolide	Andrographis paniculata	7	Squamous Cell Carcinoma of Esophagus, Multiple Sclerosis, Cognitive Impairment, Migraine Disorders, Arthritis Rheumatoid, Acute Respiratory Infections.	[79]
Artemisinin	Artemisia annua L.	161	Schizophrenia, Malaria, Plasmodium Falciparum Malaria, Malaria in Pregnancy, Uncomplicated Falciparum Malaria, Vivax Malaria, Human Papilloma Virus Infection, Pre-Cancerous Dysplasia, Cervical Dysplasia, Metastatic Breast Cancer, Cytomegalovirus Infections, Increased Drug Resistance, Colorectal Cancer, Bowel Cancer, HIV, G6PD Deficiency, Schistosoma Haematobium and Schistosoma Mansoni.	[64,80,81]
Betulin	Betula spp.	4	Epidermolysis Bullosa, Wounds, Burns.	[82]
Betulinic acid	Betula pubescens, Hypericum lanceolatum	2	Dysplastic Nevus Syndrome, Anxiety, Psychological Stress.	[82,83]
Boswellic acid	Boswellia serrata	4	Relapsing Remitting Multiple Sclerosis, Renal Stones, Knee Osteoarthritis, Joint Pain, Stiffness.	[79]
Geraniol	Cinnamomum tenuipilum, Valeriana officinalis	2	Coronary Artery Disease, Uterine Cervical Dysplasia, Papillomavirus Infections.	[84]
Ginkgolides	Ginkgo biloba	7	Intravenous Alteplase Thrombolysis, Neurological Improving, Allergy, Ischemic Stroke.	[85]
Gossypol	Gossypium hirsutum L.	21	Recurrent Adrenocortical Carcinoma, Stage III and IV Adrenocortical Carcinoma, Extensive Stage Small Cell Lung Cancer, Unspecified Adult Solid Tumor, Adult Glioblastoma, Adult Gliosarcoma, Recurrent Adult Brain Tumor, Chronic Lymphocytic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Follicular Lymphoma, Adenocarcinoma of the Prostate, Prostate Cancer, Diffuse Large Cell Lymphoma, Mantle Cell Lymphoma, Laryngeal Cancer, Brain and Central Nervous System Tumors.	[80]
Limonene	Citrus spp., Apium graveolens	10	Breast Cancer, Allergic Contact Dermatitis Due to Cosmetics, Obesity.	[86]
Lupeol	Hymenocardia acida	2	Acne.	[83]
Triptolide	Tripterygium wilfordii	4	HIV-infection/AIDS, Advanced Cancer, Gastric Cancer, Breast Cancer, Pancreatic Cancer, Prostate Cancer, Metastatic Colorectal Cancer, Solid Tumor, Solid Carcinoma, Solid Carcinoma of Stomach, Cancer of Stomach.	[64,85,87]
Ursolic acid	Rosmarinus officinalis, Malus domestica, Salvia officinalis, Thymus vulgaris	2	Metabolic Syndrome X, Sarcopenia.	[88]