Figure 5.

Zebra fish embryos were transplanted with the OCI-Ly3 cell line and treated with KAN0441571C for three days. (a) Photographs of only the tumor area days 0, 1 and 3 in zebra fishes transplanted with stained OCI-Ly3 in untreated and 1000 nM treated zebra fishes. (b) Tumor size (ratio) (mean ± SEM) in KAN0441571C treated zebra fishes at days 0, 1 and 3. A total of 21 zebra fish embryos were included in each treatment group. A statistically significant decrease in relative tumor size was noted in the treatment groups receiving the highest dose of KAN0441571C (250 nM and 1000 nM resp.) comparing day 0 with day 1 (** p < 0.01) and day 0 with day 3 (*** p < 0.001).